The Unfavored: Judah and Saul in the Narratives of Genesis and 1 Samuel

In this dissertation I focus on the fate of the unfavored within Israel: Judah in the Joseph cycle (Genesis 37-50), and Saul in the episode depicting his brief reign (1 Samuel 13-15). These two narratives contain segments that have long puzzled their readers: chapters 38 and 49 of Genesis, and the account of Saul’s first rejection in 1 Samuel 13:7b-15a seem awkward in their literary context. The bulk of my thesis consists of a thought experiment. I attempt to read these stories of Israel’s election first without and then with these intrusive segments, in order to see what the outcome might mean both in terms of hermeneutics and the notion of election

The monitoring of power system events on transmission and distribution level by the use of phasor measurements units

ABSTRAC

Familial hypercholesterolaemia in children and adolescents from 48 countries: a cross-sectional study

Background: Approximately 450 000 children are born with familial hypercholesterolaemia worldwide every year, yet only 2·1% of adults with familial hypercholesterolaemia were diagnosed before age 18 years via current diagnostic approaches, which are derived from observations in adults. We aimed to characterise children and adolescents with heterozygous familial hypercholesterolaemia (HeFH) and understand current approaches to the identification and management of familial hypercholesterolaemia to inform future public health strategies. Methods: For this cross-sectional study, we assessed children and adolescents younger than 18 years with a clinical or genetic diagnosis of HeFH at the time of entry into the Familial Hypercholesterolaemia Studies Collaboration (FHSC) registry between Oct 1, 2015, and Jan 31, 2021. Data in the registry were collected from 55 regional or national registries in 48 countries. Diagnoses relying on self-reported history of familial hypercholesterolaemia and suspected secondary hypercholesterolaemia were excluded from the registry; people with untreated LDL cholesterol (LDL-C) of at least 13·0 mmol/L were excluded from this study. Data were assessed overall and by WHO region, World Bank country income status, age, diagnostic criteria, and index-case status. The main outcome of this study was to assess current identification and management of children and adolescents with familial hypercholesterolaemia. Findings: Of 63 093 individuals in the FHSC registry, 11 848 (18·8%) were children or adolescents younger than 18 years with HeFH and were included in this study; 5756 (50·2%) of 11 476 included individuals were female and 5720 (49·8%) were male. Sex data were missing for 372 (3·1%) of 11 848 individuals. Median age at registry entry was 9·6 years (IQR 5·8-13·2). 10 099 (89·9%) of 11 235 included individuals had a final genetically confirmed diagnosis of familial hypercholesterolaemia and 1136 (10·1%) had a clinical diagnosis. Genetically confirmed diagnosis data or clinical diagnosis data were missing for 613 (5·2%) of 11 848 individuals. Genetic diagnosis was more common in children and adolescents from high-income countries (9427 [92·4%] of 10 202) than in children and adolescents from non-high-income countries (199 [48·0%] of 415). 3414 (31·6%) of 10 804 children or adolescents were index cases. Familial-hypercholesterolaemia-related physical signs, cardiovascular risk factors, and cardiovascular disease were uncommon, but were more common in non-high-income countries. 7557 (72·4%) of 10 428 included children or adolescents were not taking lipid-lowering medication (LLM) and had a median LDL-C of 5·00 mmol/L (IQR 4·05-6·08). Compared with genetic diagnosis, the use of unadapted clinical criteria intended for use in adults and reliant on more extreme phenotypes could result in 50-75% of children and adolescents with familial hypercholesterolaemia not being identified. Interpretation: Clinical characteristics observed in adults with familial hypercholesterolaemia are uncommon in children and adolescents with familial hypercholesterolaemia, hence detection in this age group relies on measurement of LDL-C and genetic confirmation. Where genetic testing is unavailable, increased availability and use of LDL-C measurements in the first few years of life could help reduce the current gap between prevalence and detection, enabling increased use of combination LLM to reach recommended LDL-C targets early in life

Design of Compression Members for Durability

General principles of structural elements design for durability and their application in the case of compression members are presented in this paper. The degradation effects of material deterioration due to corrosion cause the loss of member resistance, but the limit states method does not directly reflects design and verification allowing for failures caused by material deterioration. The time-dependent loss of compression member resistance was computed for specific corrosion models to express the time-dependent approximation function taking into account effects of corrosion degradation. Then, the design member resistance could be obtained using buckling member resistance multiplied by a timedependent function considering corrosion degradation effects within the member lifetime

Numerical Analysis of the Bridge Orthotropic Deck Time Dependent Resistance

Resistance of the stiffened plated orthotropic deck of bridge with ballast bed is affected by the environmental action effects due to unchecked corrosion process of steel bridge deck under ballast bed. Therefore, to observe the behaviour and resistance of those types of steel bridges, the probabilistic nonlinear finite element analysis using adequate sophisticated software is needed. The paper presents results of the parametric numerical analysis of the time dependent resistance of bridge with ballast bed on the orthotropic deck considering corrosion attack using ANSYS software support module PDS. Random variables entering calculations were described by means of parameters of probability density functions according to data determined experimentally. The model takes also into account the geometrical and material nonlinearities of bridge structure including the selected corrosion models

Probabilistic Analysis of Resistance Degradation under Corrosion

To observe the behaviour and resistance of steel bridges with the orthotropic plate decks, the nonlinear finite probabilistic model in the ANSYS software environment was developed using software support module PDS. Random variables were described by means of parameters of probability density function according to data determined experimentally. The model takes also into account the geometrical and material nonlinearities of the structure. The major aim of the paper is to obtain the corrosion effects influence on the resistance of this structural system. Therefore the time variant loss of member resistance was computed based on selected corrosion models

After Collecting – Leitfaden für den Kunstnachlass

'After Collecting' ist ein Praxisleitfaden für Erben, Sammler und Künstler, die das Problem "Künstlernachlass" bzw. "Kunstnachlass" rechtzeitig angehen und ihren Nachlass selbst in die Hand nehmen möchten.  Interessant ist das Buch nicht nur für Sammler und Künstler, sondern auch für Mitarbeiter von Museen, Galeristen, Kunstberater und Juristen, die mit Kunstsammlern oder ihren Erben zusammenarbeiten

Sequential Therapy for Helicobacter pylori Infection in Treatment-naïve Children

The goal of first-line Helicobacter pylori therapy is to reach an eradication rate of 90% to avoid further investigations, antibiotic use, and spreading of resistant strains. To evaluate the eradication rate of high-dose sequential therapy in treatment-naïve children and to assess factors associated with failure. Prospective data assessed in a registry from nine European centers between October 2009 and December 2011. Children with biopsy-proven Helicobacter pylori infection were prescribed 5 days of esomeprazole and amoxicillin, followed by 5 days of esomeprazole, clarithromycin, and metronidazole according to bodyweight. Eradication was assessed after 8-12 weeks. Primary endpoint was the eradication rate in children who received at least one dose and had follow-up data. Multivariate analysis evaluated potential factors for treatment success including sex, age, center, migrant status, antibiotic resistance, and adherence to therapy. Follow-up was available in 209 of 232 patients (age range 3.1-17.9 years, 118 females). Primary resistance occurred for clarithromycin in 30 of 209 (14.4%), for metronidazole in 32 (15.3%), for both antibiotics in 7 (3.3%), and culture failed in 6 (2.9%). Eradication was achieved in 168 of 209 children (80.4%, 95% CI 75.02-85.78), in 85.8% with no resistance, 72.6% with single resistance, and 28.6% with double resistance. Independent factors affecting eradication rate included resistance to clarithromycin (adjusted ORs 0.27 (0.09-0.84), p = .024), to metronidazole (0.25 (0.009-0.72), p = .010) or to both (0.04 (0.01-0.35), p = .004), and intake of ≤90% of prescribed drugs (0.03 (0.01-0.18), p < .001). A high-dose 10-day sequential therapy cannot be recommended in treatment-naïve childre